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PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS CONTAINING OLIGOSACCHARIDES AS ACTIVE COMPONENTS AND FOR PRODUCING THE ACTIVE COMPONENTS
PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS CONTAINING OLIGOSACCHARIDES AS ACTIVE COMPONENTS AND FOR PRODUCING THE ACTIVE COMPONENTS
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机译:包含寡糖的活性成分的药物组合物的制备方法和活性成分的制备方法
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摘要
Process for the preparation of oligosaccharides by a controlled chemical depolymerization of natural polysaccharides, such as heparins, heparan sulfates, dermatan sulfates, chondroitinsulfates, hyaluronic acid, by a radicalic reaction in an aqueous solution, at a temperature ranging between 20 DEG and 70 DEG C., in the presence of a catalyst selected in the group consisting of Cu++, Fe++, Cr+++, Cr2O7- as well as the resulting oligosaccharides and their related pharmaceutical compositions. The products exhibit high antithrombotic activity, little or no anticoagulant activity, high fibinolytic activity an antiinflammatory activity.
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