SALTS OF(3S(Z))-2-(((1-(2-AMINO-4-THIAZOLYL)-2-((2,2-DIMETHYL-4-OXO-1-(SULFOOXY)-3-AZETIDINYL)-AMINO)-2-OXOETHYLIDENE)-AMINO)OXY)ACETIC ACID,PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

In accordance with the present invention an orally active monosulfactam antibiotics having a crystalline structure and thereby improved stability are disclosed. The antibiotics comprise the dierythromycin (M(+)=erythromycin.H(+)) salt or the dicholine (M(+)=HOCH2CH2N(+)(CH3)3) salt of the acid (M(+)=H(+)) having the formula IMAGE that is, [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy )-3-azetidinyl]-amino]-2-oxoethylidene]amino]oxy]acetic acid.