process for the manufacture of acid 7 - (d - (-) - alpha - amino - and alpha - (p - idrossifenil) acetamido) - 3 - (1, 2, 3 - triazol - 4 (5) -) tiometil - 3 - 4 - carboxylic cefem 1.2.- propilenglicolato and intermediate alogenato of said process

摘要

Cefatrizine 1,2-propylene glycolate is prepared by reacting p-hydroxyphenylglycine chloride hydrochloride with 7-amino-3-iodomethyl-3-cephem-4-carboxylic acid, and then reacting the thus obtained novel intermediate, 7-[D(-)- alpha -amino- alpha -(p-hydroxyphenyl)-acetamido]-3-iodomethyl-3-cephem-4-carboxylic acid, with the sodium salt of 1,2,3-triazol-4(5)-thiol in 1,2-propylene glycol. The addition of water to the reaction mixture causes the cefatrizine, 1,2-propylene glycolate to precipate.