Enantioselective synthesis of 1,3,4,6,7,12B (S)- hexahydro-2H-bezo (B) furo (2,3-A) quinolizin-2-one

摘要

The present invention is directed to an enantioselective synthesis of 1,3,4,6,7,12b(S)-hexa­hydro-2H-benzo[b]furo[2,3-a]quinolizin-2-one of formula which is an intermediate in the production of the α₂-­adrenergic antagonist (2R,12bS)-N-(1,3,4,6,7,12-­hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-yl)-N-­methyl-2-hydroxy-ethanesulfonamide hydrochloride.