An enantioselective synthesis of l,3,4,6,7,l2b(S)-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-one of formula provides a key intermediate for the preparation of the α₂-adrenergic antagonist (2R,l2bS)-N-(l,3,4,6,7,l2-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-yl)-N-methyl-2-hydroxyethanesulfonamide hydrochloride, useful as an anti-depressant.
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