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Crosslinked polyacrylamide-sulfhydryl gel and sulfhydryl-functionalized derivatives thereof
Crosslinked polyacrylamide-sulfhydryl gel and sulfhydryl-functionalized derivatives thereof
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机译:交联聚丙烯酰胺-巯基凝胶及其巯基官能化的衍生物
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摘要
A water-insoluble, crosslinked polyacrylamide copolymer comprising crosslinked polyacrylamide copolymer chains of recurring monomeric structural units comprising residues of acrylamide, bisacrylamide or analogs thereof, and N,Nʹ-bisacrylylcystamine or analogs thereof. The crosslinked copolymer can be formed into discrete particles characterized by having crosslinking disulfide groups on their external surface which can be reduced to provide exposed chemically active sulfhydryl groups. The activated polyacrylamide particles can be reacted with suitable haptens and other biologically active substances to provide insolubilized forms thereof.
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