Therapeutic agent for hypertension Therapeutic composition containing the same and method for preparing hypertension therapeutic agent and composition

摘要

(Benzothiadiazine, benzamido and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds. Compounds of this invention are useful as antihypertensive agents and for the treatment of glaucoma. The dipeptide compounds are represented by formula (I), wherein W is (II), (III), (IV) and (V), n is 0 or 1; m is 0 to 2; p and q are each 0, 1 or 2, provided that the sum of p and q is 1 or 2, and that in formula (V), p is not 0; Y is -CH2-, -CH2O- or -CH2S-, attached at the 2 or 4 position of phenyl group; Z is (VI), (VII) wherein A is Cl or CF3; D is -(CH2)u-, -CH2O-, -CH2S-; (VIII) G is -CONR7(CH2)t-, or -SO2NR7(CH2)t-; t is 0 or 1. For the definition of R?1, R2, R3, R4, R5, R6, R7, R8 and R9¿ reference is made to the specification.