HUMAN-HUMAN HYBRIDOMAS FOR CERVICAL CARCINOMA

摘要

The antibodies for distinguishing cervical carcinoma cells from normal cells may be obtd. from human hybridomas CLNH5 or 11. The antibodies or their fragments may be labelled, e.g. with a radionucleotide or toxin. The human hybridoma is obtd. by fusion of B-lymphocytes (from human lymphnodes, lymphglands, bone marrow, spleen or blood, associated with a neoplasm) with a human fusion parther. The hybridomas are cloned, and the resulting clones are screened for prodn. of monoclonal anti-bodies specific for the tumour cells. The specific clones are then grown to produce the antibodies.