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The manufacturing methods of the replaced heidelo berndio e indidan and niuta heidelo petren
The manufacturing methods of the replaced heidelo berndio e indidan and niuta heidelo petren
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机译:替代的印度海德罗和纽塔海德罗的制造方法
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摘要
Tricyclic benzo fused compounds of the formula IMAGE (I) and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2R4, COR5, C(OR7)R5R6, CN, CONR9R10, CH2NR9R10, CH2NHCOR11, CH2NHSO2R12, 5-tetrazolyl or when n is 1, Q and OR1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.
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机译:式<图像>(I)的三环苯并稠合化合物及其药学上可接受的阳离子和酸加成盐,其中n为零,1或2,t为1或2; M为CH或N,R 1为H或某些酰基; Q是CO 2 R 4,COR 5,C(OR 7)R 5 R 6,CN,CONR9R 10,CH 2 NR 9 R 10,CH 2 NHCOR 11,CH 2 NHSO 2 R 12,5-四唑基或当n为1时,Q和OR1一起形成内酯或其某些还原的衍生物; Z是某些烷基,烷氧基,烷氧基烷基,芳烷基,芳烷氧基,芳氧基烷基或芳烷氧基烷基,是有价值的中枢神经系统活性剂,其使用方法,含有它们的药物组合物及其某些中间体。
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