H_2-interfering antagonist compound

摘要

Compounds constituted by ascorbyl derivatives of H2-receptor antagonists of formula CHEM or the O-alkylidene, 5,6-diacyl, 6-acyl derivatives thereof having two to sixteen carbon atoms, or a 6-phosphate, where X may be 1, 2 or 3 and Y may be 1 or 2, R1 and R2 are both hydrogen or R1 may be hydroxyl and R2 hydrogen, Z being an hydrogen atom or an alkali or alkaline-earth metal, preferably sodium, potassium or calcium, and R3 an organic base with one or more basic functional groups, having H2-receptor antagonist properties, possibly as a salt of an organic acid, at least one mole, selected from the group constituted by aspartic acid, glutamic acid, caffeic acid, ferulic acid and gallic acid, capable of reacting with nitrous acid, and a process for the preparation of said compounds. It is also described the process for the preparation of the new compounds in the presence of fatty acids.