5,10-DIHYDRO-11H-DIBENZO-(B,E)(1,4)-DIAZEPINE-11-ONS SUBSTITUTED IN POSITION 5 OR THEIR PHYSIOLOGICALLY COMPATIBLE SALTS WITH INORGANIC OR ORGANIC ACIDS SHOWING ANTIULCEROUS AND SECRETION-SUPPRESSING ACTIVITY

摘要

Novel 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones of the formula I and their physiologically tolerable salts with inorganic or organic acids, in which R1 denotes hydrogen or chlorine, R2 denotes hydrogen or methyl, R3 denotes hydrogen, methyl or 2-hydroxyethyl, R4 denotes 2-hydroxyethyl, N-morpholylcarbonylmethyl or 2-acetylaminoethyl or R3 and R4, together with the N atom to which they are bonded, denote a piperazine radical which is substituted on the imino group by a (2-furanyl)carbonyl, an acetyl or a 3,4,5-trimethoxybenzoyl radical, and A denotes a group of the formula -CH2-, -CH2-CH2- or -CH(CH3)- or a direct bond, can be prepared, inter alia, by reacting a 5,10-dihydro-5-haloacyl-11H-dibenzo[b,e]- [1,4]diazepin-11-one of the formula II in which R1, R2 and A have the abovementioned meaning and X denotes a halogen atom, with an amine of the formula III in which R3 and R4 have the abovementioned meaning, or a hydrochloride of an amine of the formula III. The compounds of the formula I have an excellent antiulcerative and secretion-inhibiting action.