New oxime derivs. of macrolide antibiotic S541

摘要

Macrotide antibiotic S541 oxime derivs. of formula (I) and their salts are new; where R1=methyl, ethyl or isopropyl; R2=H, 1-8C alkyl or 3-8C alkenyl, the groupNOR2 being in the E-configuration; an OR3=OH or substd. hydroxy group contg. upto 25 C-atoms. (I) may be prepd. by reaction of the corresponding oxo cpds. (II) with a reagent H2NOR2 or a salt thereof and, if desired, removing the portecting group from a resulting cpd.. (I) in which OR3 is a protected OH group. Cpds. (I) in which R2 is 1-8C alkyl or 3-8C alkenyl and OR3 is substd. hydroxy may be prepd. from corresponding cpds. in which OR3 is unsubstd. OH by reaction with a suitable O-substituting reagent.