6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4- hydroxypyran- 2-one inhibitors of cholesterol biosynthesis

摘要

Certain trans-6- (substituted)quinolinyl!ethyl!-and ethenyl!tetrahydro- 4-hydroxypyran-2-ones and the corresponding dihydroxy ring-opened acids derived therefrom are potent inhibitors of the enzyme 3- hydroxy-3- methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.