NOVEL CHALCONE DERIVATIVE AND ANTIULCER AGENT CONTAINING SAID DERIVATIVE AS ACTIVE INGREDIENT

摘要

NEW MATERIAL:A compound expressed by formula I [R1-R6 are H, OH, X or OX (X is straight-chain alkyl which may be substituted by OH, halogen or alkoxyl) or, together with the adjacent groups, represent alkylenedioxy, A is OH or O-Y-Z (Y is straight-chain alkylene; Z is carboxyl, alkoxycarbonyl or OH); B is -CH2-, -CO or -CH(OH)-; the dotted line represents single or unsaturated bond]. EXAMPLE:1-(2,4-6-Trihydroxyphenyl)-3-(3,4,5-trihydroxyphenyl)-1 -propanone. USE:Ad antiulcer agent. PREPARATION:Groups OH of compounds expressed by formulas II and III as raw materials are partially or wholly protected and then reaction is carried out to provide a compound expressed by formula IV, which is subsequently deprotected to afford the aimed substance.