Process for preparing a biologically active, post- translationally modified protein hormone which is composed of several subunits, a eucaryotic cell which is transfected with one or more expression vectors and is able to produce such a hormone, and expression vector which comprises heterologous DNA which encodes the subunits of the hormone, a set of expression vectors in which each vector comprises heterologous DNA which encodes a different one of the subunits of the hormone, and a process for producing a pharmacetuial preparation.

摘要

Somatostatin peptides containing at least one residue of formula (a), (b) or (c IMAGE wherein one of Y1 and Y2 is hydrogen and the other is hydroxy or both are hydrogen, each of f and g independently is 0 or 1, one of X1 and X2 is hydrogen and the other is hydrogen or an amino protecting group, and X3 is C2-4 alkylene, the free bond in each residue (a), (b) or (c) being located at the N-terminal group of the peptide, and the physiologically-acceptable others and physiologically-hydrolysable and - acceptable esters thereof when the peptide contains at least one residue of formula (a) or (b), in free form, salt form or complex form have pharmacological activity, in particular GH-, gastric and pancreatic secretion inhibiting activity.