oligopeptides with cyclic, proline analogue amino acids, and pharmaceutical acceptable salts thereof, and their use

摘要

The invention relates to compounds of the formula I IMAGE in which A is an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; Cyc is an optionally substituted heterocyclic carbonyl compound; D is NH, NCH3, O or CH2; E is CHOH, CO, SO or optionally N-substituted C=NH; F is O, NH, NCH3 or a bond; R4 is an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R8 is hydrogen or optionally substituted alkyl, process for the preparation thereof and the use thereof as inhibitors of prolyl hydroxylase.