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3,5-dihydroxy-6,8-nonadiensyre compounds and pharmaceutical compositions containing them as well as 5-hydroxy-3-oxo-6,8-nonadiensyreester compounds for use as starting material in their preparation
3,5-dihydroxy-6,8-nonadiensyre compounds and pharmaceutical compositions containing them as well as 5-hydroxy-3-oxo-6,8-nonadiensyreester compounds for use as starting material in their preparation
A compound for use in lowering blood cholesterol having the relative stereochemical formula:- CHEM wherein R is hydrogen, (C1-C3)alkyl, phenyl, benzyl or a conventional radical forming an ester group which is hydrolyzable under physiological conditions; R1 and R2, when taken separately, and R3 are each independently hydrogen, (C1-C3)alkyl, benzyl, naphthyl, phenyl or phenyl mono or disubstituted with the same or different substituents selected from the group consisting of F, Cl, Br, I, (C1-C3)alkyl, CF3, (C1-C3)alkoxy, benzyl and phenyl; with the proviso that at least one of R1 and R2 is other than hydrogen or (C1-C3)alkyl; and R1 and R2, when taken together, are combined with the double bonded carbon atom which they are attached to form a diradical ylidene group of the formula CHEM wherein n is 0 or 1 and Y is oxygen, OCH2, sulfur, SCH2, methylene or ethylene; or a pharmaceutically acceptable cationic salt thereof when R is hydrogen.
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