3-Piperidinyl 1,2-benzo-isoxazole derivs. of formula (I), in which alk is 1-4C alkano di-yl, Z is S, -CH2- or -CR1=CR2- and A is 1,1-ethano di-yl, 1,3-propano di-yl or -CR3=CR4-, with anti-psychotic and anti-serotonin activity, are made by cyclising an oxime of formula (II) in an inert solvent, opt. in presence of a base and conversion to a salt if desired.
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