New 2-piperidinyl:methyl-1,2,3,4-tetra:hydro-isoquinoline derivs. - with selective action on HT one A serotoninergic receptors, e.g. for treating depression and cardiovascular disease

摘要

Ni(piperidinylmethyl) -tetrahydroisoquinoline derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new: R = (a) H; (b) 1-6C alkyl, allyl, 3-6C cycloalkylmethyl, benzyl (opt. substd. by 1-3 of halo, CF3, NO2, NH2, NMe2, CN, CONH2, or 1-3C alkyl, alkoxy or alkylthio), 2-phenylethyl, 3-phenylpropyl, 3-phenylpropen-2-yl, phenylcarbonylmethyl, naphthylmethyl, pyridylmethyl, furanylmethyl, or thienylmethyl; (c) 2-6C alkanoyl, 3-6C cycloalkylcarbonyl, CF3CO, phenylcarbonyl (opt. substd. by halo, CF3, NO2 or 1-3C alkyl, alkoxy or alkylthio), 1-oxo-3-phenylpropen-2-yl, naphthylcarbonyl, pyridinylcarbonyl, furancarbonyl, thienylcarbonyl or 2- or 5-indolylcarbonyl.