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reduced peptides hemmungsstoffe gastric excretion, process for manufacture and pharmaceutical compositions containing them.
reduced peptides hemmungsstoffe gastric excretion, process for manufacture and pharmaceutical compositions containing them.
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机译:还原的肽血丝虫病胃排泄物,其制备方法和含有它们的药物组合物。
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摘要
The invention relates to the peptides of the formula: IMAGE (I) IMAGE in which: R1 represents hydrogen or a protecting group for the amine group, such as t-butoxycarbonyl, benzyloxycarbonyl or lower alkanoyl groups; X represents beta-alanine glycine or a direct bond between R1 and the amine group; and R2 represents a group chosen from: IMAGE corresponding to the side chains of the natural amino acid leucine, methionine and norleucine. These peptides inhibit gastric secretion.
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机译:本发明涉及下式的肽:(IMAGE)(I),其中:R1代表氢或胺基保护基,例如叔丁氧羰基,苄氧羰基或低级烷酰基。 X代表β-丙氨酸甘氨酸或R1和胺基之间的直接键; R 2代表选自以下的基团:,其对应于天然氨基酸亮氨酸,蛋氨酸和正亮氨酸的侧链。这些肽抑制胃分泌。
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