首页>
外国专利>
ELECTROCHEMICAL ASSAY FOR CIS-DIOL USING METALLOCENE BORONIC ACID
ELECTROCHEMICAL ASSAY FOR CIS-DIOL USING METALLOCENE BORONIC ACID
展开▼
机译:茂金属硼酸电化学法测定联苯二酚
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention disclosed relates to an electrochemical assay which is particularly concerned with an assay for the presence of, or amount of, glycosylated haemoglobin in a blood sample, but which extends to a general assay for detecting the presence of, monitoring the level of or determining the concentration of compounds containing cis-diol groups, such as glycols, nucleic acid components, sugars, polyols, catechols and glycosylated proteins. When ferrocene boronic acid or a derivative thereof is present free in solution, it can act as a mediator for a wide range of oxido-reductases. However in the presence of, for example, sugars containing the cis-diol structure, the metallocene (such as ferrocene boronic acid) covalently binds to the sugar. When the ferrocene boronic acid is thus bound, it is essentially immobilized and its properties as a mediator and ability to diffuse will be markedly affected.
展开▼