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Monoclonal anti-human breast cancer antibodies, their production and use, and hybridomas for producing the same and their preparation
Monoclonal anti-human breast cancer antibodies, their production and use, and hybridomas for producing the same and their preparation
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机译:单克隆抗人乳腺癌抗体,它们的产生和用途以及用于产生该抗体的杂交瘤及其制备
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摘要
Murine monoclonal antibodies are prepared and characterized which bind selectively to human breast cancer cells, are IgGs or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than about 10 nM. Methods for diagnosing, monitoring, and treating human breast cancer with the antibodies or immunotoxins made therefrom are described.
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