L-ascorbic acid which comprises (a) forming a substantially anhydrous slurry of 2-keto-l-gulonic acid and at least one lipophilic surfactant having a low hydrophilic:lipophilic balance of from about 4.3 to about 10.2 in a supporting organic layer which optionally contains a co-solvent and (b) reacting said slurry with a substantially anhydrous hydrogen chloride gas acid catalyst to convert said 2-keto-l-gulonic acid to L-ascorbic acid."/> Production of L-ascorbic acid from 2-keto-L-gulonic acid with an acid catalyst and a lipophilic surfactant having a low hydrophilic: lipophilic balance under substantially anhydrous conditions
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Production of L-ascorbic acid from 2-keto-L-gulonic acid with an acid catalyst and a lipophilic surfactant having a low hydrophilic: lipophilic balance under substantially anhydrous conditions

机译:在基本上无水的条件下,由2-酮-L-古洛糖酸用酸催化剂和亲油性表面活性剂生产L-抗坏血酸,该亲和性表面活性剂的亲水性:亲脂性平衡低

摘要

A method for producing L-ascorbic acid which comprises (a) forming a substantially anhydrous slurry of 2-keto-l-gulonic acid and at least one lipophilic surfactant having a low hydrophilic:lipophilic balance of from about 4.3 to about 10.2 in a supporting organic layer which optionally contains a co-solvent and (b) reacting said slurry with a substantially anhydrous hydrogen chloride gas acid catalyst to convert said 2-keto-l-gulonic acid to L-ascorbic acid.
机译:一种生产 L -抗坏血酸的方法,该方法包括(a)形成基本上无水的2-酮- l -古洛糖浆酸和至少一种亲油性表面活性剂在支持有机层中的亲水性平衡低至约4.3至10.2的至少一种亲油性表面活性剂,该有机层可任选包含助溶剂,并且(b)使所述浆液与基本上无水的氯化氢气体酸催化剂反应,得到将所述的2-酮基- l -古洛糖酸转化为 L -抗坏血酸。

著录项

  • 公开/公告号EP0324261A1

    专利类型

  • 公开/公告日1989-07-19

    原文格式PDF

  • 申请/专利权人 PFIZER INC.;

    申请/专利号EP19880312161

  • 发明设计人 LOZANOV MERRILL;

    申请日1988-12-22

  • 分类号C07D307/62;

  • 国家 EP

  • 入库时间 2022-08-22 06:34:03

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