PROCESS FOR THE PREPARATION OF SALICYLIC DERIVATIVES OF N-ACETYL CYSTEINE

摘要

S-salicylyl-N-acetylcysteine of formula (I) is prepared by reacting N-acetylcystine and salicylic acid as in the following, (A), The reactive deriv. selected from the salts of acetylsalicylic acid or mixed anhidrides is reacted with ethylchloroformate. (B), This product is reacted with N-acetylcysteine at low temp. in the presence of organic or inorganic base. (C), After the produced thioester is isolated, this is converted to their organic or inorganic salts in the hydrophillic, alcoholic or ketonic solvents. In (I), X is hydrogen, alkali metal, alkali earth metal or organic base. (I) is useful for antipyretics, antiinflammatories, analgesics and mucolytics.