Compositions of hormonally active human and porcine inhibin containing an amp;agr; chain and 62 chain

摘要

DNA encoding the prepro inhibin &agr; and &bgr; chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin &agr; or &bgr; chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.