N-substituted-hexahydro-1,2,5-triazepines

摘要

Disclosed herein are N-substituted-hexahydro-1,2,5-triazepines of formula I, which is ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1 -C.sub.4 alkyl;PPR.sup.1 is (R.sup.6). sub.2 --CH--(CH.sub.2).sub.n -- in which n is 0, 1, 2 or 3 and R.sup.6 is p-fluoro, chloro or methoxyphenyl; andPPR.sup.3 is hydrogen and R.sup.2 is benzoyl, 2,6-dimethyl or diethylbenzoyl, 2,6- dichlorobenzoyl, N-methyl, ethyl or propylcarboxamido, N- phenylcarboxamido, N-2,6-dimethyl or diethylphenylcarboxamido, N-2,6- dichlorophenylcarboxamido, N-methyl, ethyl or propylacetamido, N- phenylacetamido, N-2,6-dimethyl or diethylphenylacetamido, or N-2,6- dichlorophenylacetamido orPPR.sup.2 and R.sup.3 are the same and are N-methyl, ethyl or propylcarboxamido, benzoyl, 2,6-dimethyl or diethlbenzoyl, 2,6-dichlorobenzoyl, benzyl, 2,6-dimethyl or diethlbenzoyl, 2,6-dichlorobenzoyl, or a removable amino protective group. Also disclosed are N-substituted-hexahydro-1,2,5-triazepines of formula II in which R.sup.1 of formula I is replaced by R.sup.7 which is C.sub.1 - C.sub.4 alkyl, and R.sup.2 and R.sup.3 of formula I are replaced by R. sup. 8 and R.sup.9 which are, respectively, N-2,6-dimethyl, diethyl or dichlorophenylcarboxamido or N-2,6-dimethyl, diethyl or dichlorophenylacetamido and hydrogen. The compounds of the invention have antiarrhythmic properties or are intermediates for the preparation thereof.