Methods for prevention of post-inflammatory hyperpigmentation

摘要

Compositions of hydroquinone and an aliphatic sulfoxide of the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyl, substituted alkyl, alkenyl, or hetero groups, along with appropriate pharmaceutical diluents, excipients, and/or adjuvants are disclosed. The preferred aliphatic sulfoxide is dimethyl sulfoxide, and the sulfoxide content can range between about 1 and 99 weight percent, preferably between about 25 and 90 weight percent. The hydroquinone content ranges between about 1 and 10 weight percent, preferably between about 1.5 and 5 weight percent. PPAlso disclosed are various methods for preventing, eliminating, or substantially reducing post-inflammatory hyperpigmentation by applying these compositions to hyperpigmented tissue of hyman or animal subjects as often as necessry to remedy or alleviate the hyperpigmentation.