CHROMONE DERIVATIVE, PRODUCTION OF SAME CHROMONE DERIVATIVE AND ANTITUMOR AGENT CONTAINING CHROMONE DERIVATIVE AS ACTIVE INGREDIENT

摘要

NEW MATERIAL:A compound expressed by formula I (R1 is H or lysinyl; R2 is hydroxyphenylthio, ethylthio, propylthio, butylthio, methylsulfinyl, ethylsulfinyl, propylsulfinyl, butylsulflnyl, hydroxyanilino or 4'-L-lysinyloxyanilino). EXAMPLE:5,7-dihydroxy-2-(4'-hydroxyphenylthio)-6-methoxychromone. USE:Antitumor agent. PREPARATION:A compound expressed by formula II (A1 is H, OH or lower alkoxy; A2 is hydroxyphenyl or lower alkyl) is reacted with a compound expressed by the formula A3SH (A3 is hydroxyphenyl or lower alkyl) to afford a compound expressed by formula III.