PURPOSE: To obtain the subject composition capable of alleviating contraction function insufficiency and reducing tissue necrosis, by administration during both coronary atresia and reperfusion periods or during only a perfusion period, comprising a potassium tube activator. CONSTITUTION: This composition comprises a potassium tube activator, has inhibitory effects on spontaneous mechanical activity preferably at a rat portal vein, namely =2M IC50 and is composed, for example, of (+)-2-cyano-1-(4- pyridyl)-3-1(1,2,2-trimethylpropyl)guanidine and ()-6-cyano-3,4-dihydro-2,2- dimethyl-trans-4-(2-oxo-1-pyrrolidyl)-2H-benzo[b]-pyran-3-ol. Preferably, the composition is locally administered to a coronary arteries by arterial vascular contrastradiography or injection in a corona by a catheter and its dose is 0.001-30mg/kg/time, preferably 0.5-25mg/kg/time.
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机译：目的：通过在冠状动脉闭锁和再灌注期间或仅在灌注期间施用，获得包含钾管激活剂的，能够减轻收缩功能不足和减少组织坏死的主题组合物。组成：该组合物包含钾管活化剂，对自发机械活性具有抑制作用，优选在大鼠门静脉处，即<= 2M IC50，并且由例如（+）-2-cyano-1-（4-吡啶基）-3-1（1,2,2-三甲基丙基）胍和（）-6-氰基-3,4-二氢-2,2-二甲基-反-4-（2-氧代-1-吡咯基）- 2H-苯并[b]-吡喃-3-醇。优选地，通过动脉血管造影术或通过导管在日冕中将组合物局部施用至冠状动脉，并且其剂量为0.001-30mg / kg /次，优选0.5-25mg / kg /次。
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