INHIBITION OF CELL-CELL AND CELL-GROUND SUBSTANCE INTERACTION THROUGH INHIBITION OF CARBON HYDRATE-CARBON HYDRATE INTERACTION

摘要

PURPOSE: To suppress the metastasis of malignant tumor cell and microbial infection of warm blooded animals and prevent the conception of warm blooded animals by administering the animal with an agent for inhibiting carbohydratecarbohydrate interaction. CONSTITUTION: The cell-cell interaction or cell-substrate interaction of a warm- blooded animal is inhibited in vivo or in vitro by using an agent for inhibiting carbohydrate-carbohydrate interaction, e.g. a saccharide, a glyco-conjugate such as oligosaccharide linked to a peptide (e.g. lysyllysine) or an antibody against a carbohydrate determining group (preferably a monoclonal antibody). When one of the constituents of said interaction is present in the malignant tumor cell, the metastasis of the cell is suppressed and when it is present in a microorganism (bacteria, virus, true fungi or parasite), the infection with the microorganism is suppressed. The contraception of a warm blooded animal can be achieved by an agent effective for inhibiting a carbohydrate-carbohydrate interaction between the sperm and the ovum.