The invention provides a new derivative of vitamin D3, 24,24-difluoro-25-hydroxycholecalciferol. The compound is characterized by vitamin D-like activity in its ability to increase intestinal calcium transport, increase serum calcium and inorganic phosphorous concentration and to prevent the development of rickets. It would find ready application as a substitute for vitamin D3 and in the treatment of disease states evincing calcium-phosphorous imbalance and which are non-responsive to vitamin D3 therapy.
展开▼
