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Analogifremgangsmaade for the preparation of daunorubicin and doxorubicinanaloge
Analogifremgangsmaade for the preparation of daunorubicin and doxorubicinanaloge
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机译:类比免疫球蛋白制备柔红霉素和阿霉素类似物
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IMAGE The anthracycline glycosides I (X = H or OH, R1 = H or CH3, R2 = H or OCH3, R3 = H or OCH3, R2 = R3) and their pharmaceutically acceptable acid addition salts have antitumour properties. They are prepared from 4-demothoxy-daunomycinone or 2,3-dimethyl-4-methoxy-daunomycinone by condensation with an appropriate N-protected hexopyranosyl chloride and removal of the protecting group and, in the case X = OH, conversion of the 9-acetyl group to a 9-hydroxyacetyl group.
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