首页> 外国专利> A process for preparing an inactivated combination vaccine READY FOR ADMINISTRATION, THE ACTIVE AGAINST NEWCASTLE DISEASE-INDUCED BY AND AEGPRODUKTIONSFALD adeno-like viruses

A process for preparing an inactivated combination vaccine READY FOR ADMINISTRATION, THE ACTIVE AGAINST NEWCASTLE DISEASE-INDUCED BY AND AEGPRODUKTIONSFALD adeno-like viruses

机译:制备准备用于行政管理的主动灭活联合疫苗的方法,该活性是针对由腺样病毒诱发和由其诱导的新城疫的

摘要

Combined, inactivated vaccine, ready for administration and active against at least Newcastle disease and egg production drop caused by adeno like viruses and process for the preparation of such vaccine. The vaccine is prepared by addition of a Newcastle disease virus (NDV) containing liquid, obtained by cultivation of a NDV, followed by inactivation of this liquid and optionally homogenizing it, together with an adeno like virus (ALV) containing liquid, obtained by cultivation of an ALV, followed by inactivation of this liquid and optionally homogenising it, to an oily phase containing as essential components at least one of the components selected from the group consisting of light mineral paraffinic oils, plant oils and naphtenic mineral oils and one or more emulsifiers, such as non ionic surface-active compound derived from alkylene oxide and/or hexahydric alcohols and/or higher natural fatty acids such as esters or ester-ethers, optionally followed by homogenising and/or addition of a preservative.
机译:组合的灭活疫苗,易于给药,对至少由腺样病毒引起的新城疫和产蛋量下降具有活性,并且制备这种疫苗的方法。通过添加含有新城疫病毒培养液的新城疫病毒(NDV),灭活该液并任选使其均质化,以及通过培养获得的含有腺样病毒(ALV)的液来制备疫苗ALV,然后将该液体失活并任选使其均质化为油相,该油相包含至少一种选自轻矿物石蜡油,植物油和萘基矿物油的成分作为基本成分和一种或多种乳化剂,例如衍生自环氧烷和/或六元醇和/或高级天然脂肪酸(例如酯或酯醚)的非离子型表面活性化合物,可选地随后进行均质化和/或添加防腐剂。

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