ANALOGIFREMGANGSMAADE for preparing 4- (substituted alkyl) -N- (1,3-dithiolane-2-ylidene) anilines or pharmaceutically acceptable acid addition salts thereof

摘要

N-(1-3-dithiolan-2-ylidene)-4-alkylanilines having a hydroxy, alkoxy or alkanoyloxy substituent on the alkyl group are useful as anti-inflammatory agents, as analgesic agents and as antiasthmatic agents. The compounds involved can be prepared by the reaction of an appropriate 4-alkylaniline with a methyl(1,3-dithiolan-2-ylidene)sulfonium salt or with carbon disulfide and ethylene dibromide in the presence of a base.