N-substituted 2- (phenyl or bicyclo (2.2.1) hept-2-yl) oxynicotinamid compounds, such compounds for therapeutic use, and their use for the preparation of medicaments for the treatment of depression

摘要

Certain N-substituted nicotinamide compounds having formula (I) below CHEM and pharmaceutically acceptable acid addition salts thereof wherein R1 is 1-piperidyl, 1-(3-indolyl)ethyl, C1-4 alkyl, phenyl, 1-(1-phenylethyl), benzyl or mono-substituted benzyl wherein the substituent is methyl, methoxy, chloro or fluoro; and R2 is bicyclo[2.2.1]hept-2-yl or CHEM wherein Y is hydrogen, fluoro or chloro; and X is hydrogen, fluoro, chloro, methoxy, trifluoromethyl, cyano, carboxy, carbo(C1-4 alkoxy), methylcarbamoyl or dimethylcarbamoyl function as selective inhibitors of calcium-independent phosphodiesterase and are useful as antidepressants.