PROCESS FOR PRODUCTION OF MEDICAL COMPOSITIONS CONTAINING 5-HYDROXI AND 5-METOXI-2-AMIN-PIRIMIDINES HINDERING THE PRODUCTION OF INTERLEUCIN-1

摘要

This invention relates to the use of certain derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines of the formula CHEM and the pharmaceutically-acceptable salts thereof, wherein R1 is H or CH3; R2 is CH3; R3 is (C3-C15) straight chain alkyl or (C7-C20)phenylalkyl which may be substituted in the phenyl by one or two fluoro or chloro substituents; and R4 is H or CH3 to inhibit interleukin-1 production in a mammal. This invention also relates to the use of such compounds for treating interleukin-1 mediated disorders and dysfunctions such as bone and connective tissue metabolism disorders and immune dysfunction in a mammal. The methods of this invention comprise administering an interleukin-1 production inhibiting amount of the compounds and salts of this invention to such a mammal.