PHARMACEUTICAL AROMATASE-INHIBITING COMPOSITIONS CONTAINING PHENYL-SUBSTITUTED IMIDAZO(1,5-A)PYRIDINE AND IMIDAZO(1,5-A)AZACYCLOALKANE DERIVATIVES,CERTAIN SUCH DERIVATIVES AND THEIR PREPARATION

摘要

Compounds of the formula IMAGE (Ia) wherein R1 represents cyano, nitro or C1-C4-alkyl or the 7,8-dihydro derivative thereof or the 5,6,7,8 tetrahydro derivative of the formula IMAGE (Ib) wherein R1 is as defined under formula Ia and R2 is hydrogen, C1-C4-alkyl, halogen etherified or esterified hydroxy or mercapto, carboxy-C1-C4-alkyl or C1-C4-alkoxycarbonyl-C1-C4-alkyl or C1-C4-alkanoyl, to stereoisomers, mixtures of these stereoisomers and salts of these compounds are disclosed as well as their preparation, pharmaceutical compositions containing the same and the use thereof as inhibitors of aromatase activity.