CONTROLLED RELEASE TABLET HAVING CORE CONTAINING WATER - SWELLABLE POLYMER AND COATING OF SEMIPERMEABLE POLYMERIC DIFFUSION FILM

摘要

A controlled release tablet comprisingPP(I) a core, containing as essential componentsPP(a) at least one water-soluble pharmaceutically active substance which is dispersed in a water-insoluble, non-digestible polymeric excipient, andP P (b) a water-insoluble polymeric substance, which is swellable under the influence of water, andPP(II) a coating essentially of an elastic, water-insoluble and semipermeable diffusion film of a polymer, PPis presented, which shows a release pattern for the active substance(s) in a programmed rate of approximately zero order.