NIEUWE DERIVATEN VAN BENZYLIDEEN-CYCLANONEN, DE BEREIDING DAARVAN, DE TOEPASSING DAARVAN ALS ANTI-OXYDATIEMIDDELEN EN ALS ZONNEFILTERS, EN KOSMETISCHE EN FARMACEUTISCHE PREPARATEN DIE DEZE BEVATTEN.

摘要

Benzylidenecyclanone compounds of formula: IMAGE [in which: R1 and R are independently hydrogen, hydroxyl, C1-C8 alkyl or C1-C8 alkoxy (with the reservation that at least one of the radicals R1 and R is other than hydrogen); R2 and R3 are independently hydrogen or hydroxyl (with the reservation that at least one of the radicals R2 and R3 is hydroxyl); R4, R5, R6 and R7 are independently C1-C18 alkyl, aralkyl (optionally substituted by C1-C4 alkyl or C1-C4 alkoxy), aryl (optionally substituted by C1-C4 alkyl); or the substituents R4 and R5 and/or the substituents R6 and R7 form, together with the carbon atom of the ring to which they are attached, a saturated ring containing from 5 to 12 carbon atoms which is optionally substituted by one or more C1-C8 alkyl(s); and X is CH2, (CH2)2 or N-R8 (in which R8 is hydrogen, C1-C8 alkyl, aralkyl (optionally substituted by C1-C4 alkyl or C1-C4 alkoxy), hydroxyl or C1-C8 alkoxy) or alternatively X is oxygen or sulphur] have anti-oxidant and wide-band sunscreening properties and are useful constituents of cosmetic preparations. Such compounds are also pharmaceutically useful in the treatment of inflammations and allergies of the skin and in the prevention of certain cancers.