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Use of a Human Rhinovirus (HRV) Head Receptor Preparation for the Preparation of a Drug for Inhibiting the Initiation or Spread of Rhino Virus Infection
Use of a Human Rhinovirus (HRV) Head Receptor Preparation for the Preparation of a Drug for Inhibiting the Initiation or Spread of Rhino Virus Infection
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机译:人类鼻病毒(HRV)头受体制剂在制备抑制鼻病毒感染的起始或传播的药物中的用途
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摘要
A water soluble human rhinovirus (HRV) major receptor preparation comprising detergent-complexed glycoprotein isolated from animal cells, preferably mammalian cells, that express the HRV major receptor and which exhibits the ability to bind to HRV capsids to substantially reduce infectivity of the virus. The purified, water soluble receptor is obtained by extracting cells expressing the receptor with detergent and isolating the solubilized detergent-glycoprotein complexes by binding to monoclonal antibody selective for the HRV receptor protein.
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