3-PROPENYLCEPHEM DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS; PROCESSES FOR PREPARATION

摘要

A 3-propenylcephem derivative of the following formula: CHEM wherein R1 represents a fluoro-substituted lower alkyl group or a cyano-substituted lower alkyl group, and A represents a cyclic or an acylic ammonio group, or a pharmaceutically acceptable salt thereof, exhibiting excellent anti-bacterial activities against both Gram-positive bacteria and Gram-negative bacteria; Process for the preparation thereof; Anti-bacterial composition; Intermediate for the 3-propenylcehem derivative; and Process for the preparation of the intermediate.