METHOD FOR PREPARING NEW DERIVATIVES OF 6- OR 7-METHYLENANDROSTA-1,4-DIENE-3,17-DIONA AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention relates to new 6- or 7-methylenandrosta-1,4-diene-3,17-diones of the following formula CHEM wherein R is hydrogen or fluorine; R1 is hydrogen or C1-C6 alkyl; R2 is hydrogen or halogen; one of R3 and R4 is =CH2 and the other is hydrogen or C1-C4 alkyl, and when R3 is =CH2, at least one of R and R4 is other than hydrogen; and the symbol @ @@ represents a double bond and the symbol @@@ represents a single bond when R3 is =CH2 or the symbol @@@ represents a single bond and the symbol @@@ represents a double bond when R4 is =CH2, which are useful in therapy, in particular as anti-cancer agents.