METHOD AND MEANS FOR THE SELECTION OF ANTI-IDIOTIPOSAL ANTIBODIES AND THEIR USE FOR DIAGNOSIS, MONITORING, TREATMENT AND / OR PREVENTION OF CANCER, AUTOMOBILE, OR INFECTIOUS DISEASES

摘要

A selective anti-idiotype therapies of cancer, infectious disease or autoimmune disease, allergy or transplantation rejection. Prognostic idiotopes useful in disease diagnosis and/or monitoring are (i) identified and (ii) induced or suppressed by the therapeutic application of modulatory anti-idiotype antibodies, alone or in combination with other immunomodulating agents. Modulatory anti-idiotype antibodies and methods for making and using them in immunotherapy are claimed. Modulatory anti-idiotype antibodies may be made and used in active or passive immunotherapy according to the following method. First, idiotype bearing antibodies (Ab1s) are generated or acquired. Second, select at least one idiotype bearlng Ab1 or T-cell which is reactive with a cancer, infectious agent or autoimmune disease target antigen, allergen or transplant antigen for future screening. Next, make at least one anti-id (Ab2) against the Ab1 or T-cell receptor. At this point, the anti-ids (Ab2s) made are screened. Each of the anti-ids (Ab2s) may be screened either against the B or T-cell idiotopes of either the sera, blood or tissue of a statistically significant panel of patients or against the serum, blood or tissue of a single patient or animal. In either case, the purpose of the screening is to identify a correlation between idiotope level and either (i) disease presence or progression, or (ii) disease absence or regression. Finally, that anti-id (Ab2) or combination of anti-ids (Ab2s) which induces either (1) suppression of idiotopes which normally fall with disease regression; (2) stimulation of idiotopes which normally rise with disease regression; (3) stimulation of idiotopes which normally fall with disease progression; or (4) suppression of idiotopes which normally rise with disease progression are administered.