Water-soluble hydroxy-flavone ethers are novel cpds. comprising 5-R10- 7-R0-3'-R2-4'-methoxy-flavones of formula (I) (where R is H, -CH2-CH2-OH or 6-O-alpha-L-rhamnosyl-D-glucosyl; R1, R2 independently are H or -CH2-CH2-OH. In the broadest definition (not claimed) -CH2-CH2-OH groups are changed to substd-alkyl.) Used to treat vascular permeability and fragility by oral, rectal, parenteral or topical admin. in doses of 50-300 mg 3-8 times daily. In capillary fragility tests (Charlier et al technique) (I) show equal to superior activity to diosime and superior activity to ruten. They are used to treat venous troubles, such as varicose and haemorrhoidal troubles, haemorrhagic diatheses and purpura, retinopathies and arteriolites in hypertension and diabetes, gastro-duoderal ulcers, ulcerocas colitis, metrorrhages etc.
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