method for nuclear magnetic resonance tomography of nuclei to bassaconcentrazione and / or low isotopic abundance and / or relationship giromagnetco than protonic and / or long time to relaxssamento spin lattice based on double resonance techniques, in particular for biological and clinical investigation

摘要

The object of the present invention consists in the development and use of a method for nuclear magnetic resonance tomography of nuclei with a low concentration and/or low abundance of isotopes and/or with a gyromagnetic ratio less than that of the protons and/or with a long spin-lattice relaxation time, based on double resonance techniques, in particular for biological and clinical investigations. Said method is based on the heteronuclear J coupling between the aforesaid rare and/or low-sensitivity nuclei and other nuclei of a more abundant and/or more sensitive kind, which is typically - but not necessarily - hydrogen. The position of the rare nuclei is visualized by an image of the abundant nuclei linked to the former by a J coupling. IMAGE