ENRICHMENT OF ANTIGEN-SPECIFIC POLYCLONAL ANTIBODIES THROUGH SELECTION OF IMMORTAL HYBRID CELLS

摘要

Methods of preparing polyclonal antibody compositions of high titers and desired specificity for use in immunoassay diagnostic procedures are disclosed. The processes employ immortalized cells cultured as pools or enriched, for example by adsorption onto a specific solid support matrix, and/or stimulated for proliferation by transformation, as pools for subsequent culturing. The resulting compositions have higher specificity and titer than polyclonal antiserum.