Antisense-oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (Tat) of HIV-I, and their use

摘要

The present invention relates to chemically modified antisense oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (tat) of HIV-1 and to the use thereof in pharmaceuticals. The chemically modified antisense oligonucleotides have antiviral effects. The pharmaceuticals can be used for the therapy of HIV infections. The antisense oligonucleotides are suitable as gene probes for detecting HIV.