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Inhibition of eukaryotic pathogens and neoplasms by soluble peptides and stimulation of fibroblasts and lymphocytes
Inhibition of eukaryotic pathogens and neoplasms by soluble peptides and stimulation of fibroblasts and lymphocytes
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机译:可溶性肽抑制真核病原体和肿瘤以及刺激成纤维细胞和淋巴细胞
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摘要
Inhibition of eucaryotic pathogens and neoplasms and stimulation of lymphocytes and fibroblasts with lytic peptides such as cecropins and sarcotoxins. Eucaryotic cells are contacted with cecropin or sarcotoxin, or a synergistic combination of cecropins or sarcotoxin with lysozyme, in an amount effective to lyse or inhibit the cells. Target cells include eucaryotic microorganisms such as protozoa, e.g. T. cruzi and P. falciparum, mammalian lymphomas and leukemias, and cells infected with intracellular pathogens such as viruses, bacteria and protozoa. Also disclosed is a method for stimulating proliferation of lymphocytes and fibroblasts by contacting such cells with an effective amount of cecropin or sarcotoxin. The methods may be in vitro or in vivo.
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