KANAMYCIN TANNATE ITS PREPARATION AND ITS USE AS ANTIBIOTIC-ANTIDIANJETIC AND PHARMACEUTICAL COMPOSITIONS

摘要

Kanamycin tannate is prepd. by reacting kanamycin base MeOH soln. (A) with tannic acid MeOH soln. (B) (wt. ratio of A:B= 3:2) at room temp. and atmospheric pressure for 5 hrs.. (A) is obtd. by reacting kanamycin sulfate monohydrate with methanol suspension of ammonia gas. (B) is purified by gallic acid and pyrogallol. The kanamycin tannate is useful as antibacterial agent with antidiarrhoeal activity.