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New kanamycin - c - derivatives, processes for their preparation and pharmaceutical compositions containing same
New kanamycin - c - derivatives, processes for their preparation and pharmaceutical compositions containing same
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机译:新卡那霉素-C-衍生物,其制备方法和含有该衍生物的药物组合物
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摘要
NEW KANAMYCIN C DERIVATIVES 1-N-(L-4-amino-2-hydroxybutyryl) derivatives of kanamycin C, 3'-deoxykanamycin C and 3',4'-dideoxykanamycin C have been prepared which possess high antibacterial activity against a wide variety of drug-resistant bacteria. These new derivatives are prepared by reacting L-4-amino-2-hydroxybutyric acid or a functional equivalent thereof with the l-amino group of kanamycin C, 3'deoxykanamycin C or 3',4'-dideoxykanamycin C.
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